Immune System Boost (Thymosin Alpha 1)
Boost Your Immune System with Thymosin alpha 1 (Tα1)
- Regulates immune system response
- Modulates anti-viral cytokine production
- Promotes T-cell maturation and differentiation
- Upregulates MHC Class 1 expression
- Inhibits viral replication
What is Thymosin alpha 1 (Tα1)?
Thymosin alpha 1 is a naturally occurring thymic polypeptide of 28 N-terminally acetylated amino acids. Wells Pharmacy Network compounds the synthetically manufactured peptide Thymosin alpha 1 (Tα1) in a sterile solution for subcutaneous injection. It is prepared in a vial at a concentration of 3mg/ml in a 5ml solution. Tα1 is a powerful modulator of immunity and inflammation. It has been demonstrated, in over 70 clinical studies, to improve the immune response to multiple strains of viruses, including SARS, HIV, hepatitis B and C.
Thymosin alpha 1 exhibits a pleiotropic mechanism of therapeutic action, upregulating the innate immune response when required, and downregulating it when not needed. Tα1 acts as a multitask protein restoring immune system homeostasis and cell-mediated immune function in various pathological and physiological conditions, including viral infections.
How does Tα1 help the immune system?
Thymosin alpha 1 induces host-derived immune effectors and balances the Th1 and Th2 responses.
The effector cells improve various immunomodulatory properties, augmenting T-lymphocyte function, via:
- modulation of interleukin-2 (IL-2)
- stimulation of interferon-g (IFN-g) production
- induction of T lymphocyte cells
- induction of natural killer (NK) cells
- stimulation of thymopoiesis
Studies show that Thymosin alpha 1:
- increases major histocompatibility complex (MHC) class-1 and Toll-like receptor expression
- downregulates terminal deoxynucleotide transferase (TdT) activity in TdT1 thymocytes
- antagonizes activation induced (anti-CD3) and glucocorticoid-induced thymocyte apoptosis
- stimulates Indoleamine-2,3-Dioxygenase (IDO) activity
- increases FoxP3 IL-10 producing regulatory T cells
- plays a role in feedback inhibition of cytokine production
- dampens immune response to prevent a pro-inflammatory cytokine storm
What are Tα1 use cases?
Thymosin alpha 1 has been studied or is currently under investigation for use in the following cases:
- prophylactic use
- influenza (multiple types, including Coronavirus / COVID)
- chronic hepatitis B
- chronic hepatitis C
- malignant melanoma
- hepatocellular carcinoma
- DiGeorge’s syndrome with immune defects
What is the track record of Tα1 use so far?
Thymosin alpha 1 has been used in:
- over 70 clinical studies
- over 3,000 patients
- age ranges from 13 months to 101 years
- wide range of immunocompromised patients
What is the Thymosin alpha 1 safety profile?
Thymosin alpha 1 peptide given subcutaneously is reported safe and efficacious in recommended dosages. Tα1 has been demonstrated to have a very favorable toxicity profile. Over 3,000 individuals have been treated with Tα1 to date, including patients with hepatocellular carcinoma, non–small-cell lung cancer, melanoma, and hepatitis B and C. Thymosin alpha 1 has been reported to be well tolerated even in patients with decompensated liver disease, renal disease requiring hemodialysis and primary immunodeficient individuals.
What are Tα1 contraindications and adverse events?
As with all injections, redness and pain at the site of injection may be present. Rare adverse reactions include erythema, transient muscle atrophy, polyarthralgia combined with hand edema, and rash. A transient increase in ALT to more than twice baseline value can occur during Tα1 therapy. When ALT flare occurs, Thymosin alpha 1 should generally be continued unless signs and symptoms of liver failure are observed. Caution should be used if administering to pregnant or nursing women. Tα1 should not be used on individuals being deliberately immunosuppressed.
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- I learned so much about my body and my health by completing 3 of the test that Dr Guglin recommended. I'm very impressed by the technology available here in Milford CT. The staff is knowledgeable, professional and most of all caring. If you spend time at the Gym, you definitely want to know more about your body. I highly recommend HyperFit MD.- Clem Yazdani. 7/17/2019
- My experience at Hyper Fit MD Age Management Center has been and continues to be positive with excellent results. Dr. Guglin and Francesca are professional and caring individuals who provide detailed personal service. In my opinion, this is the wave of the future. If you adhere to your personalized plan, as I have, the results are excellent. I would highly recommend Dr. Guglin to improve your health and life. V. Lazzaro- Vin Lazz. 6/11/2019
- Dr.Guglin and Francesca are outstanding people. They're professional, personable, compassionate, and really cared about my experience and well-being throughout my NeoGraft procedure. Dr. Guglin is an esteemed medical doctor, having years of surgery experience. In addition to their team doing a remarkable job, they made sure I was comfortable the whole time, and even provided lunch. They made the whole process relatively stress free, despite it being an all-day procedure, and even finished ahead of schedule. They are always accessible and responsive. I strongly recommend Dr. Guglin and his team. Salt of the earth people.- Doug Rudolph. 5/14/2019
- HyperFit Age Management offers a unique approach to health care ... Preventative/Functional medicine. Dr. Guglin is passionate about educating his patients so that they can live their best lives. He uses advanced diagnostics and a variety of cutting edge treatments. While other doctors just treat symptoms by writing an RX, Dr. Guglin gets to the cause of the problem. If you are sick and tired of being sick and tired, make an appointment today!- Michele Kelly. 3/23/2019
- All of the attention to wellness that you expect from your doctor but don't get. I am very pleased with the focus on keeping well and maintaining an optimized body. I learned more about my body in 2 visits than I have in 45 years visiting various General Practitioners. I highly recommend them.- Brett Calkins. 0/16/2019
- Dr Guglin fixed my hormones very quickly. Bio-denticals are life changing when you have the right Doctor. He spends a lot of time going over test results. Your not rushed like at your primary physician. His wife Francesca is so kind and helpful . She greets you at the front desk. Overall a great experience.- Christine Ann. 0/15/2019
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